HNF1B |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2DA6, 2H8R | | |
Ідентифікатори |
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Символи | HNF1B, FJHN, HNF-1B, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF-2, TCF2, VHNF1, HNF-1-beta, HNF1 homeobox B, T2D, ADTKD3, RCAD |
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Зовнішні ІД | OMIM: 189907 MGI: 98505 HomoloGene: 396 GeneCards: HNF1B |
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Пов'язані генетичні захворювання |
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цукровий діабет 2-го типу, endometrial cancer, рак простати[1] |
Онтологія гена |
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Молекулярна функція | • DNA binding • sequence-specific DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding |
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Клітинна компонента | • transcription regulator complex • нуклеоплазма • клітинне ядро |
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Біологічний процес | • Сигнальний шлях Notch • pronephros development • mesonephric tubule development • endoderm development • GO:0009373 regulation of transcription, DNA-templated • GO:1904578 response to organic cyclic compound • mesonephric duct development • endodermal cell fate specification • розвиток нирки • mesonephric duct formation • ureteric bud elongation • protein-DNA complex assembly • negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis • hindbrain development • hepatocyte differentiation • epithelial cell proliferation • insulin secretion • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • response to glucose • positive regulation of transcription initiation from RNA polymerase II promoter • nephric duct formation • circadian regulation of gene expression • transcription, DNA-templated • regulation of branch elongation involved in ureteric bud branching • negative regulation of mesenchymal cell apoptotic process involved in metanephros development • epithelium development • nephric duct development • genitalia development • pronephric nephron tubule development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • hepatoblast differentiation • regulation of Wnt signaling pathway • GO:1901313 positive regulation of gene expression • inner cell mass cell differentiation • embryonic morphogenesis • kidney morphogenesis • embryonic digestive tract morphogenesis • liver development • regulation of endodermal cell fate specification • branching morphogenesis of an epithelial tube • response to carbohydrate • regulation of pronephros size • anterior/posterior pattern specification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • endocrine pancreas development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • pancreas development |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | ENSG00000276194 ENSG00000275410 |
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UniProt | | |
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RefSeq (мРНК) | | NM_000458 NM_001165923 NM_001304286 NM_006481 |
| | NM_001291268 NM_001291269 NM_009330 |
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RefSeq (білок) | | NP_000449 NP_001159395 NP_001291215 NP_001159395.1 |
| | NP_001278197 NP_001278198 NP_033356 |
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Локус (UCSC) | Хр. 17: 37.69 – 37.75 Mb | Хр. 11: 83.74 – 83.8 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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