GPR50

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G protein-spregnuti receptor 50
Identifikatori
SimboliGPR50; H9; MGC125342
Vanjski IDOMIM: 300207 MGI: 1333877 HomoloGene: 3113 IUPHAR: GPR50 GeneCards: GPR50 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu sličnog receptora
• receptorska aktivnost
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• međućelijska signalizacija
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez924814765
EnsemblENSG00000102195ENSMUSG00000056380
UniProtQ13585Q3V1S8
RefSeq (mRNA)NM_004224XM_990925
RefSeq (protein)NP_004215XP_996019
Lokacija (UCSC)Chr X:
150.1 - 150.1 Mb		Chr X:
67.92 - 67.93 Mb
PubMed pretraga[1][2]

GPR50, G protein-spregnuti receptor 50, je protein koji je kod čoveka kodiran GPR50 genom.[1][2][3]

Funkcija

GPR50 je član GPCR familije integralnih membranskih proteina. On je sličan melatoninskom receptoru.[2] GPR50 ima sposobnost formiranja heterodimera sa MT1 i MT2 melatoninskim receptorima. Dok GPR50 nema uticaja na MT2 funkciju, on sprečava MT1 da veže melatonin i formira kompleks sa G proteinima.[4]

Klinički značaj

Određeni polimorfizmi GPR50 gena kod žena su povezani sa povišenim rizikom razvoja bipolarnog poremećaja, kliničkom depresijom, i šizofrenijom.[5] Drugi GPR50 genski polimorfizmi uslovljavaju povišenje nivoa cirkulišućih triglicerida i sniženje nivoa cirkulišućih lipoproteina visoke gustine.[6]

Literatura

  1. ↑ „Entrez Gene: GPR50 G protein-coupled receptor 50”. 
  2. ↑ 2,0 2,1 Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (May 1996). „Cloning of a melatonin-related receptor from human pituitary”. FEBS letters 386 (2-3): 219–24. DOI:10.1016/0014-5793(96)00437-1. PMID 8647286. 
  3. ↑ Gubitz AK, Reppert SM (January 1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)”. Genomics 55 (2): 248–51. DOI:10.1006/geno.1998.5661. PMID 9933574. 
  4. ↑ Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization”. The EMBO journal 25 (13): 3012–23. DOI:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767. 
  5. ↑ Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (May 2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor”. Molecular psychiatry 10 (5): 470–8. DOI:10.1038/sj.mp.4001593. PMID 15452587. 
  6. ↑ Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (April 2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels”. Journal of lipid research 47 (4): 761–6. DOI:10.1194/jlr.M500338-JLR200. PMID 16436372. 

Dodatna literatura

  • Reppert SM, Weaver DR, Ebisawa T, et al. (1996). „Cloning of a melatonin-related receptor from human pituitary.”. FEBS Lett. 386 (2-3): 219–24. DOI:10.1016/0014-5793(96)00437-1. PMID 8647286. 
  • Gubitz AK, Reppert SM (1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50).”. Genomics 55 (2): 248–51. DOI:10.1006/geno.1998.5661. PMID 9933574. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Slominski A, Pisarchik A, Zbytek B, et al. (2003). „Functional activity of serotoninergic and melatoninergic systems expressed in the skin.”. J. Cell. Physiol. 196 (1): 144–53. DOI:10.1002/jcp.10287. PMID 12767050. 
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). „Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”. Genome Res. 14 (9): 1711–8. DOI:10.1101/gr.2435604. PMC 515316. PMID 15342556. 
  • Thomson PA, Wray NR, Thomson AM, et al. (2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.”. Mol. Psychiatry 10 (5): 470–8. DOI:10.1038/sj.mp.4001593. PMID 15452587. 
  • Bhattacharyya S, Luan J, Challis B, et al. (2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.”. J. Lipid Res. 47 (4): 761–6. DOI:10.1194/jlr.M500338-JLR200. PMID 16436372. 
  • Levoye A, Dam J, Ayoub MA, et al. (2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.”. EMBO J. 25 (13): 3012–23. DOI:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767. 
  • p
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)