Tenilapine
Atypical antipsychotic
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Formula | C17H16N4S2 |
Molar mass | 340.46 g·mol−1 |
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Tenilapine is an atypical antipsychotic which has never been marketed in the US.
Pharmacodynamics
Tenilapine has a relatively high affinity for the 5-HT2A receptor, and relatively low (micromolar) affinities for dopamine receptors.
Receptor | Ki (nM) |
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D2 | 1584[1] |
D4 | 721±300[1] |
5-HT2A | 40[1] |
The ratio of D2 to D4 bonding is similar to that of clozapine.[1] Like many other atypical antipsychotics, it is a potent 5-HT2C antagonist.[2]
References
- ^ a b c d Roth BL, Tandra S, Burgess LH, Sibley DR, Meltzer HY (August 1995). "D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs". Psychopharmacology (Berl). 120 (3): 365–8. doi:10.1007/BF02311185. PMID 8524985. S2CID 13549491.
- ^ Di Giovanni G, Esposito E, Di Matteo V (2011). "The 5-HT2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from Electrophysiological and Neurochemical Studies". 5-HT2C Receptors in the Pathophysiology of CNS Disease. The Receptors. Vol. 22. Totowa, NJ: Humana Press. pp. 215–247. doi:10.1007/978-1-60761-941-3_11. ISBN 978-1-60761-940-6.
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Antipsychotics (N05A)
- Butyrophenones: Benperidol
- Bromperidol
- Droperidol
- Haloperidol#
- Moperone
- Pipamperone
- Spiperone
- Timiperone
- Trifluperidol
- Phenothiazines: Acepromazine
- Acetophenazine
- Butaperazine
- Carphenazine (carfenazine)‡
- Chlorpromazine
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- Dixyrazine
- Fluphenazine
- Levomepromazine (methotrimeprazine)
- Mesoridazine
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- Thiopropazate
- Thioproperazine
- Thioridazine
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- Triflupromazine
- Others/unknown: Azacyclonol
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III