PGRMC2

Protein-coding gene in the species Homo sapiens
PGRMC2
Identifiers
AliasesPGRMC2, DG6, PMBP, progesterone receptor membrane component 2
External IDsOMIM: 607735; MGI: 1918054; HomoloGene: 38169; GeneCards: PGRMC2; OMA:PGRMC2 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for PGRMC2
Genomic location for PGRMC2
Band4q28.2Start128,269,237 bp[1]
End128,288,829 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for PGRMC2
Genomic location for PGRMC2
Band3|3 BStart41,020,761 bp[2]
End41,037,481 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • islet of Langerhans

  • stromal cell of endometrium

  • epithelium of colon

  • skin of abdomen

  • skin of arm

  • skin of leg

  • adipose tissue

  • rectum

  • abdominal fat
Top expressed in
  • otic placode

  • saccule

  • supraoptic nucleus

  • otic vesicle

  • motor neuron

  • yolk sac

  • skin of external ear

  • Epithelium of choroid plexus

  • seminal vesicula

  • decidua
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • steroid hormone receptor activity
  • steroid binding
  • heme binding
  • lipid binding
  • protein binding
Cellular component
  • integral component of membrane
  • nuclear envelope
  • membrane
Biological process
  • steroid hormone mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10424

70804

Ensembl

ENSG00000164040

ENSMUSG00000049940

UniProt

O15173

Q80UU9

RefSeq (mRNA)

NM_006320

NM_027558

RefSeq (protein)

NP_006311

NP_081834

Location (UCSC)Chr 4: 128.27 – 128.29 MbChr 3: 41.02 – 41.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Progesterone receptor membrane component 2 (abbreviated PGRMC2) is a protein which is encoded by the PGRMC2 gene.[5][6] It has been detected in the placenta, liver, and spermatozoa, among other areas.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164040 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049940 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Gerdes D, Wehling M, Leube B, Falkenstein E (1998). "Cloning and tissue expression of two putative steroid membrane receptors". Biol. Chem. 379 (7): 907–11. doi:10.1515/bchm.1998.379.7.907. PMID 9705155.
  6. ^ a b Lösel R, Breiter S, Seyfert M, Wehling M, Falkenstein E (2005). "Classic and non-classic progesterone receptors are both expressed in human spermatozoa". Horm. Metab. Res. 37 (1): 10–4. doi:10.1055/s-2005-861023. PMID 15702432.
  • v
  • t
  • e
PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists
See also
Receptor/signaling modulators
Progestogens and antiprogestogens
Androgen receptor modulators
Estrogen receptor modulators
List of progestogens


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