Cloflubicyne
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IUPAC name 5,6-dichloro-3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile | |
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Properties | |
Chemical formula | C11H6Cl2F6N2 |
Molar mass | 351.07 g·mol−1 |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards | Extremely toxic |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose) | 0.1 mg/kg (intraperitoneal, mice)[1] |
LDLo (lowest published) | 0.2 mg/kg (oral, rats)[2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Cloflubicyne is a chemical compound which is a chlorinated derivative of BIDN. It is an irreversible GABA receptor antagonist with powerful convulsant effects.[3][4][5][6]
See also
- BIDN
- EBOB
References
- ^ Fetisov, V.I.; Maslov, A.A.; Panarin, V.A.; Trefilov, N.V. (August 1992). "Fluoro-containing 'cage' convulsants: inhibition of gamma-aminobutyric acid induced Cl−currents". Journal of Fluorine Chemistry. 58 (2–3): 368. doi:10.1016/S0022-1139(00)80833-7.
- ^ Middleton, W.J; Bingham, E.M (May 1982). "Fluorine-containing 1,1-dicyanoethylenes: their preparation, diels-alder reactions, and derived norbornenes and norbornanes". Journal of Fluorine Chemistry. 20 (3): 397–418. doi:10.1016/S0022-1139(00)82232-0.
- ^ Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V. (April 1996). "Norbornan, a new irreversible ligand of the GABAA-receptor chloride channels". Bulletin of Experimental Biology and Medicine. 121 (4): 404–406. doi:10.1007/BF02446741. S2CID 35092380.
- ^ Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V.; Suftin, S. G.; Garbuz, L. A. (July 1996). "Norbornane-induced changes in the density of chloride-ion channels in the brain of rodents". Bulletin of Experimental Biology and Medicine. 122 (1): 660–662. doi:10.1007/BF02446014. S2CID 46036353.
- ^ Golovko, A. I.; Ivanov, M. B.; Klyuntina, T. V.; Sofronov, G. A.; Sviderskii, O. A.; Shilov, V. V. (January 1997). "Development of increased convulsibility in mice after a single norbornan injection". Bulletin of Experimental Biology and Medicine. 123 (1): 52–54. doi:10.1007/BF02764378. S2CID 27826524.
- ^ Golovko, A. I.; Ivanov, M. B.; Sviderskii, O. A.; Sofronov, G. A.; Shilov, V. V. (June 1998). "Mechanisms of kindling induced by norbornan intoxication". Bulletin of Experimental Biology and Medicine. 125 (6): 579–581. doi:10.1007/BF02445245. S2CID 26207399.
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GABA receptor modulators
GABABTooltip γ-Aminobutyric acid B receptor |
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- See also
- Receptor/signaling modulators
- GABAA receptor positive modulators
- GABA metabolism/transport modulators
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