ANXA8L2

Protein

ANXA8L1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1W3W,%%s1W45, 1W3W

Identifiers

Aliases

ANXA8L1, ANXA8, ANXA8L2, VAC-beta, bA145E20.2, annexin A8-like 1, annexin A8 like 1

External IDs

MGI: 1201374; HomoloGene: 20393; GeneCards: ANXA8L1; OMA:ANXA8L1 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q11.22	Start	46,375,627 bp^[1]
Band	10q11.22	End	46,391,784 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14 B\|14 20.8 cM	Start	33,807,938 bp^[2]
Band	14 B\|14 20.8 cM	End	33,822,528 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of abdomen

skin of leg

mucosa of esophagus

placenta

right lung

vagina

olfactory zone of nasal mucosa

upper lobe of left lung

minor salivary glands

testicle

Top expressed in

skin of external ear

corneal stroma

conjunctival fornix

ankle

ankle joint

skin of back

skin of abdomen

decidua

esophagus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calcium-dependent phospholipid binding metal ion binding calcium ion binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding actin filament binding
Cellular component	extracellular exosome intracellular anatomical structure cytosol plasma membrane late endosome membrane collagen-containing extracellular matrix
Biological process	endosome organization endosomal transport negative regulation of serine-type endopeptidase activity negative regulation of phospholipase A2 activity hemostasis blood coagulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


728113


11752

Ensembl


ENSG00000264230


ENSMUSG00000021950

UniProt


Q5VT79 P13928


O35640

RefSeq (mRNA)


NM_001039801 NM_001098845 NM_001278923 NM_001278924 NM_001630


NM_001281845 NM_013473

RefSeq (protein)

NP_001092315 NP_001265852 NP_001265853 NP_001035173 NP_001258631
NP_001258632


NP_001268774 NP_038501

Location (UCSC)

Chr 10: 46.38 – 46.39 Mb

Chr 14: 33.81 – 33.82 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.^[5]

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000264230 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021950 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ANXA8 annexin A8".

External links

Human ANXA8 genome location and ANXA8 gene details page in the UCSC Genome Browser.
Human ANXA8L1 genome location and ANXA8L1 gene details page in the UCSC Genome Browser.

Gerke V, Moss SE (2002). "Annexins: from structure to function". Physiol. Rev. 82 (2): 331–71. doi:10.1152/physrev.00030.2001. PMID 11917092.
Gerke V, Creutz CE, Moss SE (2005). "Annexins: linking Ca2+ signaling to membrane dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 449–61. doi:10.1038/nrm1661. PMID 15928709. S2CID 37526262.
Chang KS, Wang G, Freireich EJ, et al. (1992). "Specific expression of the annexin VIII gene in acute promyelocytic leukemia". Blood. 79 (7): 1802–10. doi:10.1182/blood.V79.7.1802.1802. PMID 1313714.
Chambers JA, Gardner E, Hauptmann R, et al. (1993). "TaqI polymorphisms at the annexin VIII locus (ANX8)". Hum. Mol. Genet. 1 (7): 550. doi:10.1093/hmg/1.7.550. PMID 1364010.
Hauptmann R, Maurer-Fogy I, Krystek E, et al. (1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". Eur. J. Biochem. 185 (1): 63–71. doi:10.1111/j.1432-1033.1989.tb15082.x. PMID 2530088.
Sarkar A, Yang P, Fan YH, et al. (1994). "Regulation of the expression of annexin VIII in acute promyelocytic leukemia". Blood. 84 (1): 279–86. doi:10.1182/blood.V84.1.279.279. PMID 8018923.
Reutelingsperger CP, van Heerde W, Hauptmann R, et al. (1994). "Differential tissue expression of Annexin VIII in human". FEBS Lett. 349 (1): 120–4. Bibcode:1994FEBSL.349..120R. doi:10.1016/0014-5793(94)00559-1. PMID 8045287. S2CID 8928858.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stein T, Price KN, Morris JS, et al. (2006). "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer". Clin. Cancer Res. 11 (19 Pt 1): 6872–9. doi:10.1158/1078-0432.CCR-05-0547. PMID 16203777.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Goebeler V, Ruhe D, Gerke V, Rescher U (2006). "Annexin A8 displays unique phospholipid and F-actin binding properties". FEBS Lett. 580 (10): 2430–4. Bibcode:2006FEBSL.580.2430G. doi:10.1016/j.febslet.2006.03.076. PMID 16638567. S2CID 22336528.

PDB gallery

1w3w: THE 2.1 ANGSTROEM RESOLUTION STRUCTURE OF ANNEXIN A8
1w45: THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.