AGR3

Protein-coding gene in the species Homo sapiens
AGR3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3PH9

Identifiers
AliasesAGR3, AG3, BCMP11, HAG3, PDIA18, hAG-3, AG-3, anterior gradient 3, protein disulphide isomerase family member
External IDsOMIM: 609482; MGI: 2685734; HomoloGene: 45551; GeneCards: AGR3; OMA:AGR3 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for AGR3
Genomic location for AGR3
Band7p21.1Start16,859,412 bp[1]
End16,881,987 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for AGR3
Genomic location for AGR3
Band12|12 A3Start35,975,619 bp[2]
End35,999,735 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • mucosa of ileum

  • mucosa of sigmoid colon

  • right uterine tube

  • rectum

  • jejunal mucosa

  • mucosa of transverse colon

  • pancreatic epithelial cell

  • duodenum

  • trachea
Top expressed in
  • saccule

  • vestibular sensory epithelium

  • utricle

  • olfactory epithelium

  • primary oocyte

  • zygote

  • secondary oocyte

  • right lung lobe

  • trachea

  • cochlea
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • dystroglycan binding
Cellular component
  • endoplasmic reticulum
  • cellular component
  • intracellular membrane-bounded organelle
Biological process
  • cell differentiation
  • negative regulation of cell death
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

155465

403205

Ensembl

ENSG00000173467

ENSMUSG00000036231

UniProt

Q8TD06

Q8R3W7

RefSeq (mRNA)

NM_176813

NM_207531

RefSeq (protein)

NP_789783

NP_997414

Location (UCSC)Chr 7: 16.86 – 16.88 MbChr 12: 35.98 – 36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Anterior gradient protein 3 homolog is a protein that in humans is encoded by the AGR3 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173467 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036231 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fletcher GC, Patel S, Tyson K, Adam PJ, Schenker M, Loader JA, Daviet L, Legrain P, Parekh R, Harris AL, Terrett JA (Feb 2003). "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan". British Journal of Cancer. 88 (4): 579–85. doi:10.1038/sj.bjc.6600740. PMC 2377166. PMID 12592373.
  6. ^ Adam PJ, Boyd R, Tyson KL, Fletcher GC, Stamps A, Hudson L, Poyser HR, Redpath N, Griffiths M, Steers G, Harris AL, Patel S, Berry J, Loader JA, Townsend RR, Daviet L, Legrain P, Parekh R, Terrett JA (Feb 2003). "Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer". The Journal of Biological Chemistry. 278 (8): 6482–9. doi:10.1074/jbc.M210184200. PMID 12477722.
  7. ^ "Entrez Gene: AGR3 anterior gradient homolog 3 (Xenopus laevis)".

External links

Further reading

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Persson S, Rosenquist M, Knoblach B, Khosravi-Far R, Sommarin M, Michalak M (Sep 2005). "Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family". Molecular Phylogenetics and Evolution. 36 (3): 734–40. doi:10.1016/j.ympev.2005.04.002. PMID 15935701.


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